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Mouse Model Strain Selection Guide for Infectious Disease Studies

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This Mouse Model Strain Selection Guide was developed by the Pathogen Portal Team in collaboration with Dr. Carol Bult from The Jackson Laboratory. The table lists pathogens along with mouse strains that have been found to be either susceptible or resistant to infection with the pathogen. Links are provided to more information about the mouse strains, including ordering information. Links are also provided to publications documenting susceptibility or resistance of the mouse strains to specific pathogens.




Pathogen Name Pathogen Type Resistant Mouse Strain Susceptible Mouse Strain Humanized Mouse Pubmed ID MGI Reference
Bacillus anthracis Bacterial C3H/HeNCrj C57BL/6NCrj 2024449 11137
Bacillus anthracis (Sterne strain) Bacterial CBA/J; BALB/cJ A/J 3143893 9489
Chlamydia trachomatis Bacterial C57BL/6J C3H/HeJ 16395389 107185
Listeria monocytogenes Bacterial C57BL/6ByJ BALB/cByJ 11242105 69829
Mycobacterium tuberculosis Bacterial C57Bl/6J DBA/2J 11197687 68608
Salmonella typhi Bacterial NSG 20713716
Salmonella enteritidis Bacterial C57BL/6J 129S6/SvEvTac 15973461 101403
Yersinia pestis Bacterial BALB/cJ C57BL/6J 18573896 139988
Leishmania major Eukaryotic C57BL/6J BALB/cAN 16223880; 9151907 41070
Leishmania major Eukaryotic B10.D2/oSnJ BALB/cSim 9175833 40816
Plasmodium chabaudi Eukaryotic C57BL/6 SJL; C3H/He 21116636; 9398834 44687
Plasmodium yoelli Eukaryotic 129X1/SvJMs NC/JicJcl 11862405 93913
Plasmodium yoelli Eukaryotic BALB.D2-Mtv7 BALB/c 9207740 41787
Plasmodium berghei Eukaryotic 129S1/1vlmJ; AKR/J; SWR/J; BTBR_T+_tf/J; DBA/2J; C58/J; NZO/HILtJ; WSB/EiJ I/LnJ; RIIIS/J; CZECHII/EiJ; C3H/HeJ; BUB/BnJ; FVB/NJ; LG/J; MA/MyJ; SJL/J; SM/J; C57BL/6J; CE/J; PL/J; A/J; NZW/LacJ; CBA/J 20531941 161988
Plasmodium falciparum Eukaryotic NSG 21483851; 19596869
Dengue virus Viral NSG 19802382; 19535452; 20015996
Simplexvirus Viral C57BL/6J 129S6/SvEvTac 14557652 87168
Cytomegalovirus Viral PWK/Pas BALB/c 16622016 109170
Cytomegalovirus Viral NZW NZB 19641964 152706
Cytomegalovirus Viral NSG 20833379
Influenza Viral A2G; SL/NiA; T9; CAST/Ei C57BL/6J; C3H/HeJ; BALB/cJ; CBA/J; CE/J; I/LnJ; PERA/Ei 14193387 13088
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